Impact of the Timing of Invasive Mechanical Ventilation in Sepsis Patients

ccforum.biomedcentral.com September 13, 2024

In patients with sepsis admitted to ICU and received invasive mechanical ventilation (MV), early MV was associated with lower ICU and in-hospital mortality and a shorter ICU stay.

Additionally, at ICU discharge, early MV was linked to a reduced need for tracheostomy and a relatively lower frequency of renal replacement therapy.

We analyzed data of adult patients with sepsis between September 2019 and December 2021.

Data was collected through the Korean Sepsis Alliance from 20 hospitals in Korea. Patients who were admitted to ICU and received MV were included in the study.

Patients were divided into ‘early MV’ and ‘delayed MV’ groups based on whether they were on MV on the first day of ICU admission or later.

Propensity score matching was applied, and patients in the two groups were compared on a 1:1 ratio to overcome bias between the groups.