Early catheter-based therapie (CBT) was associated with improved clinical outcomes in patients with acute intermediate-risk pulmonary embolism (PE). The composite PE shock score may help identify patients who will benefit from early CBT. Further prospective studies are needed to validate these findings.

This retrospective cohort study analyzed data from 2 academic centers involving patients with intermediate-risk PE from January 2020 to January 2024.

Patients were divided into early (<12 hours) and delayed CBT (≥12 hours) groups. The primary outcome was a composite of 30-day mortality, resuscitated cardiac arrest, hemodynamic instability, and 90-day readmission. Secondary outcomes included a composite of 30-day mortality, resuscitated cardiac arrest, and hemodynamic instability. Inverse probability of treatment weighting was used to balance covariates.

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