Cerebral auto-regulation was altered in half of the patients with sepsis and was associated with the development of SABD.

These findings support the concept that cerebral hypoxia could contribute to the development of sepsis-associated brain dysfunction (SABD).

Mxa was 0.29. Cerebral autoregulation (CAR) was impaired in 50 patients (50%).

In a multiple linear regression analysis, low mean arterial pressure, history of chronic kidney disease and fungal infection were associated with high Mxa.

We studied 100 adult patients with sepsis (age = 62 [52–71] years) Acute Physiology and Chronic Health Evaluation II score on admission = 21.

Exclusion criteria were acute or chronic intracranial disease, arrhythmias, extracorporeal membrane oxygenation, and known intra- or extracranial supra-aortic vessel disease.

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