Increased Lactate Dehydrogenase to Albumin Ratio Associated with Short-term Mortality in Septic ICU Patients

journals.lww.com January 1, 2025

Elevated lactate dehydrogenase to albumin ratio (LAR) was found to be significantly associated with an increased risk of all-cause mortality at 28 and 90 days in septic patients. LAR was suggested to be promising biomarker for identifying septic patients with a higher risk of short-term mortality.

This retrospective study was conducted based on the Medical Information Mart for Intensive Care (MIMIC) IV database (version 2.1), which was approved by the Institutional Review Board of the Massachusetts Institute of Technology and Beth Israel Deaconess Medical Center.

Adult septic patients were included in this study.

Sepsis diagnosis was according to Sepsis 3.0 criteria.

The primary endpoint was 28-day all-cause mortality. The Secondary endpoints was 90-day all-cause mortality.