Pancreatitis, a common and challenging condition, presents frequently in emergency departments across the country, affecting around 34 of every 100,000 adults annually.

This often-severe disease is marked by inflammation of the pancreas, which can rapidly progress to multiorgan failure in its most serious forms. The optimal management strategy, particularly in the critical early hours of treatment, continues to evolve despite its frequency.

The cornerstone of early pancreatitis management has long been aggressive fluid resuscitation, typically using normal saline (NS).

The belief that large volumes of intravenous fluids could mitigate pancreatic injury by preventing ischemia was widely accepted, and normal saline has remained the first-choice fluid for decades.

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