Leptin and Linterlukin-6 Relationship and Influence of Mortality in Sepsis

link.springer.com April 8, 2025

High leptin levels might counteract the adverse prognostic effect of elevated IL-6 on septic mortality. At the same IL-6 level, leptin could predict septic mortality.

Leptin might be a protecting factor for men and gender-different signaling pathways related to sepsis need further study.

This study’s strength was focused on the relationship between different cytokines and leptin and pointed out the interaction between IL-6 and leptin.

Future research can clarify the mechanisms by which leptin influences IL-6 regulation of inflammation and further evaluate whether administering leptin in cases of high IL-6 sepsis could provide a protective effect.

The retrospective study enrolled 165 adults with sepsis from medical intensive care units (ICU)s, and collected leptin, glucose levels, and cytokines such as IL-6, IL-1RA, IL-10, IL-17, TNF-α, IFN-γfor analysis.