Patients hospitalized for sepsis with Sequential Organ Failure Assessment (SOFA) scores greater than or equal to 6 in the ICU or HDU had lower in-hospital mortality than those in the general ward, as did those with SOFA scores greater than or equal to 12 in the ICU versus high-dependency care unit (HDU).

Of 97,070 patients, 19,770 (20.4%), 23,066 (23.8%), and 54,234 (55.9%) were treated in ICU, HDU, and general ward, respectively.

After propensity score matching, the ICU + HDU group had significantly lower in-hospital mortality than the general ward group, among cohorts with SOFA scores greater than or equal to 6.

There were no significant differences in in-hospital mortality among cohorts with SOFA scores 3–5.

The ICU + HDU group had significantly higher in-hospital mortality than the general ward among cohorts with SOFA scores of 2.

The ICU group had lower in-hospital mortality than the HDU group among cohorts with SOFA scores greater than or equal to 12.

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