This study is an important step toward optimizing mechanical ventilation strategies, addressing the interplay between mechanical power, gas exchange and long-term respiratory outcomes could further refine lung-protective ventilation strategies.

The study focuses primarily on short-term ICU outcomes.

However, the impact of mechanical power modulation on long-term respiratory function and weaning success is unknown.

Given that prolonged exposure to high mechanical power may contribute to persistent lung fibrosis or impaired ventilatory mechanics, follow-up studies assessing post-ICU pulmonary function could enhance our understanding of its clinical consequences.

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