Septic shock is defined as sepsis with hypotension refractory to fluid challenge and requiring vasopressor support combined with an increase in arterial lactate reflecting impaired cellular energy metabolism and dysoxia. Te use of vasoactive drugs to restore mean arterial pressure (MAP) is strongly recommended by the Surviving Sepsis Campaign and the Task Force of the European Society of Intensive Care Medicine (ESICM) on circulatory shock management and monitoring. Resuscitation in septic shock aims to restore tissue perfusion pressure without excessive vasoconstriction, which impedes flow and paradoxically worsens organ dysfunction or leads to other adverse events.

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