Milrinone vs. Dobutamine in the Treatment of Cardiogenic Shock
nejm.orgIn patients with cardiogenic shock, no significant difference between Milrinone and Dobutamine was found with respect to the primary composite outcome or important secondary outcomes.
A total of 192 participants (96 in each group) were enrolled.
The treatment groups did not differ significantly with respect to the primary outcome; a primary outcome event occurred in 47 participants (49%) in the Milrinone group and in 52 participants (54%) in the Dobutamine group.
There were also no significant differences between the groups with respect to secondary outcomes, including in-hospital death, resuscitated cardiac arrest, receipt of mechanical circulatory support, or initiation of renal replacement therapy.