There was considerable variability in the mortality time frames reported in ICU-based septic shock trials. This variability may lead to under or overestimation of the problem, overlooking the effectiveness of the interventions studied, and further limiting the application of trials and their pooling in meta-analyses.

A consensus regarding time frame reporting in septic shock trials is long overdue.

The search yielded 2,660 unique citations.

After screening, 132 eligible studies were identified.

A total of 234 mortality time frames were collected from the included studies, of which 15 timeframes were unique.

Read More