In recent times, the applications of continuous renal replacement therapy (CRRT) beyond kidney‐related conditions have been progressively increasing, and its implementation in randomized controlled trials (RCTs) specifically for acute respiratory distress syndrome (ARDS) has been documented.

This meta‐analysis compiles all existing RCTs to assess whether CRRT benefits ARDS.

Low‐quality evidence suggests that compared with conventional therapy alone, the use of CRRT may be associated with a lower mortality rate, the incidence of VAP, ICU length of stay, mechanical ventilation time, EVLWI, APACHE II score, TNF‐α, and IL‐6 and may be related to better respiratory function.

CRRT may be beneficial for ARDS patients.

Future multicenter, well‐designed, high‐quality RCTs are needed to substantiate these findings.

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