Reversible infantile liver failure (RILF) is a heritable mitochondrial condition that causes severe liver dysfunction in infancy, but those who survive the acute stage typically recover and have no further problems. In work designed to examine the molecular mechanisms involved in RILF, researchers in Japan have used a novel murine model to show that a deficiency of the mitochondrial enzyme MTU1 has strong effects on the liver and on embryonic development in general.

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