Patients recovering from an episode of hypoxemic acute respiratory failure (hARF) may benefit from a weaning strategy based on early extubation followed by immediate noninvasive ventilation (NIV) application.

Compared to conventional weaning, replacing the endotracheal tube with a noninvasive interface reduces the duration of invasive mechanical ventilation (i-MV).

Overall time spent on mechanical ventilation, length of ICU and hospital stay, and risk of VAP may also be reduced by this weaning strategy.

Future studies are warranted to evaluate whether this approach is also associated with reduced mortality.

1,605 records were screened.

6 studies were included in quantitative synthesis.

Overall, 459 participants recovering from hARF were included in the analysis

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