In critically ill patients with severe acute kidney injury (AKI), initiation of continuous renal replacement therapy (CRRT), as compared to intermittent hemodialysis (IHD), was associated with a significant reduction in the composite outcome of death or RRT dependence at 90-days.

In this secondary analysis of the STARRT-AKI trial, the initial receipt of CRRT, as compared to IHD, was associated with a significant reduction in the risk of death or RRT dependence at 90-days, largely driven by a lower risk of RRT dependence.

These observations provide new knowledge on the potential link between RRT modality and kidney recovery.

While hypothesis generating, our findings should serve as a springboard for future randomized trials that can more rigorously assess the impact of RRT modality on clinical outcomes and healthcare costs.

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