Early and persistent improvement in oxygenation was seen only in hyperinflammatory ovine ARDS treated with methylprednisolone, while hemodynamic situation and survival was improved in both injury models and corticosteroid treatment. Erythromycin did not offer any benefit regarding all assessed outcomes.

This was a single-blinded, randomized, controlled preclinical trial in an ovine model.

A total of 30 animals were randomized and allocated to the two injury methods: oleic acid (OA, n = 15) or oleic acid and lipopolysaccharides (OA-LPS, n = 15).

For each injury model, subjects were further randomized to receive treatment either with methylprednisolone (pred: OA-LPS-pred, OA-pred; each 5 per group) or erythromycin (ery: OA-LPS-ery, OA-ery; each 5 per group) or they were randomized to the control group (ctr: OA-LPS-ctr and OA-ctr; each 5 per group).

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