Oxygenation Indices and Early Prediction of Outcome in Hypoxemic Patients with COVID-19 Pneumonia Requiring NIV Respiratory Support in Pulmonary Intermediate Care Unit

link.springer.com November 26, 2024

Oxygenation indices (OI) showed different effectiveness in predicting NIRT failure within 24 h of treatment in COVID-19 related pneumonia. This may be due to the multi-factorial pathophysiology of hypoxemia.

Our study emphasizes furthermore the role of non-oxygenation-related parameters in contributing to the outcome.

These findings may be useful to build a predictive model also in no COVID-19 related hypoxemic pneumonia.

We assessed the predictive value of SpO2/FiO2, PaO2/FiO2, standardised PaO2/FiO2 ratio (s-PaO2/FiO2), respiratory index (RI), arterial–alveolar oxygen gradient (a-ADO2), age adjusted arterial–alveolar oxygen ratio (adj-a-ADO2D).

Receiver operating characteristics (ROC), AUC and best sensitivity–specificity cut-off values were calculated at t0, t12, t24.

NIRT failure risk was adjusted for non-oxygenation predictors.