In this retrospective multicenter study, none of the selected admission and treatment variables were related to the CPPopt yield.

The median CPPopt yield was 80.7% (interquartile range 70.9–87.4%).

None of the selected variables showed a significant statistical correlation with the CPPopt yield.

Retrospective analysis of 230 patients from the CENTER-TBI high-resolution database with intracranial pressure (ICP) measured using an intraparenchymal probe.

CPPopt was calculated using the algorithm set for the COGiTATE study.

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