At centers that are resource-limited and where ADAMTS-13 testing is not readily available, it is imminent that treatment is started immediately based on the clinical presentation and PLASMIC score.

A PLASMIC score can be relied on if or when ADAMTS-13 levels would take significant time before revealing the results.

In this hematologic emergency, failure to initiate immediate measures, such as therapeutic plasma exchange and steroids, would prove detrimental to patients.

In addition, a PLASMIC score is an excellent tool that can effectively differentiate between TTP and pseudo-TMA, such as vitamin B12 deficiency.

The disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13 levels reduction is a definitive hallmark leading to microvascular thrombosis. However, some medical centers in the United States do not promptly have quick allowance to the levels.

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