This study shows changes in hematological, biochemical, and inflammatory parameters in COVID-19 non-surviving patients. Lymphopenia, neutrophilia, and thrombocytopenia, as well as increased levels of CRP, AST, creatinine, ferritin, AST, troponin I, urea, magnesium, and potassium served as prognostic markers and were associated with patient mortality.

Changes in IL-10, CCL2, CXCL9, and CXCL10 serum levels were also associated with increased mortality in patients.

Thus, this study confirms the relationship between the various biomarkers evaluated in hospitalized patients with severe COVID-19 and their relationship with fatal COVID-19.

The results corroborate previous studies conducted in other countries and reinforce the importance of identifying potential targets that can reduce the expression of these biomarkers as a strategy in treating and controlling viral respiratory infections.

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