Serum LGALS3BP and GDF-15 levels are abnormally elevated in the death group of ICU sepsis patients, suggesting potential application value as prognostic markers for sepsis.

The combined use of LGALS3BP and GDF-15 can assist clinicians in the early prediction of prognosis in sepsis patients, providing reference for physicians in developing treatment plans.

The study involved 208 sepsis patients from the ICU of our hospital. These patients were categorized based on their 28-day survival outcomes into two groups: 166 in the survival group and 42 in the mortality group.

The serum levels of LGALS3BP and GDF-15 were measured using the ELISA technique.

Pearson and Spearman methods were utilized for correlation analysis.

Factors affecting mortality in ICU sepsis patients were evaluated through multivariate logistic regression analysis.

The efficacy of these biomarkers in prognosis prediction was assessed using receiver operating characteristic (ROC) curve analysis.

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