Prevalence and Risk Factors of ICU-acquired Weakness in COVID-19 Patients

pubmed.ncbi.nlm.nih.gov August 19, 2024

The prevalence of ICUAW in patients with COVID-19 was considered relatively high. Older age, pre-existing hypertension, medical intervention of prone position, NMBA use, needed tracheostomy and RRT were likely risk factors.

In the future, interdisciplinary medical team should pay attention to high-risk groups for ICUAW prevention and early treatments.

he pooled prevalence of ICUAW in COVID-19 patients was 55% in eight studies on 868 patients.

Risk factors for developing ICUAW in these patients were: old age (WMD 4.78, 95% CI, 1.06-8.49), pre-existing hypertension (OR = 1.63, 95% CI, 1.02-2.61), medical intervention of prone position (OR = 5.21, 95% CI, 2.72-9.98), use of neuromuscular blocking agents (NMBA) (OR = 12.04, 95% CI, 6.20-23.39), needed tracheostomy (OR = 18.07, 95% CI, 5.64-57.92) and renal replacement therapy (RRT) (OR = 5.24, 95% CI = 2.36-11.63).