The use of prophylactic non-invasive ventilation (NIV) reduced reintubation rates, ICU and hospital length of stay (LOS), and mortality. These findings support the recommendation for its use in daily practice.

Rescue NIV may have reduced the re-intubation rate in control group who underwent the procedure.

Eleven studies were included in this review.

There was a difference in favor of prophylactic NIV for the outcome reintubation (odds ratio [OR]: 0.49; 95% confidence interval [CI]: 0.32, 0.74), ICU mortality (OR: 0.39; 95% CI: 0.21, 0.71), hospital mortality (OR: 0.53; 95% CI: 0.33, 0.85), ICU LOS (median [MD]: -2.86; 95% CI: −5.47, −0.24), and postextubation respiratory failure development (OR: 0.28; 95 % CI: 0.12, 0.67).

There was no difference noted for hospital LOS (MD: -0 0.42; 95% CI: -3.42, 2.59). In the subgroup analysis, the use of rescue NIV, mainly in the control group, showed no statistically significant difference in the outcomes.

Read More