Extracorporeal support modalities are highly prothrombotic. Anticoagulation is frequently used for patients receiving Continuous Renal Replacement Therapy (CRRT), Molecular Adsorbent Recirculating System (MARS), and Extracorporeal Membrane Oxygenation (ECMO).

The objective of this systematic review and meta-analysis is to determine if prostacyclin-based anticoagulation strategies are effective compared to other anticoagulation strategies, in critically ill children and adults who needs extracorporeal support, such as continuous renal replacement therapy.

We conducted a systematic review and meta-analysis using multiple electronic databases and included studies from inception to June 1, 2022.

Circuit lifespan, proportion of bleeding, thrombotic, and hypotensive events, and mortality were evaluated.

Out of 2,078 studies that were screened, 17 studies (1,333 patients) were included.

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