Administration of convalescent plasma (CP) in critically ill COVID-19 patients leads to a rapid and highly significant improvement of sequential organ failure assessment (SOFA) score along with improvements in respiratory and hemodynamic conditions.

Beyond that, our analysis suggests a time-dependent transient therapeutic effectivity of CP administration.

To this end, besides antibody titers and CP volume, a repetitive administration of CP might lower the risk of both death and severe respiratory disease progression and, thus, improve the outcome of COVID-19-induced acute respiratory distress syndrome (ARDS) patients.

There was a significant difference in sequential organ failure assessment (SOFA) score development between both groups within days 2 and 7, with highly significant differences on days 3, 4, and 6, respectively.

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