regarding the blind method, being uninformed of the clinical diagnoses of patients is unavailing, since clues will still be found in patients’ clinical manifestations.

Therefore, two trained physicians in intensive ultrasound were selected for joint measurement. After each measurement, the images were stored on the ultrasound machine, on which the optic nerve sheath diameter (ONSD) was measured. This can minimize the influence of subjective factors on the measurement.

This is perceived as an appropriate blind method.

Second, the sepsis patients included in the research were aged between 18 and 93. However, in our experiment, we did not encounter patients with split or trabecular optic nerve sheaths, nor difficulties in the measurement due to skeletal problems, though these did appear in clinical work.

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