This paper provided an overview of how ICU sedation practices have evolved over the last 20 years.

Contemporary ICU sedation practices include light levels of sedation, SAT, and use of non-benzodiazepines.

The current COVID-19 pandemic has placed unprecedented demands on ICU workforce and challenged sedation practices.

It is urgent that clinicians reengage bundled based strategies such as the ABCDEF Bundle to promote liberation from the ventilator and promote recovery and survivorship.

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