This systematic review and meta-analysis demonstrated the significant association of implementing sepsis alert systems in the Emergency Departments (ED) with patient outcomes.

These findings indicate that sepsis alert systems were not only associated with reduced mortality risk but also higher and quicker adherence to the sepsis bundle.

These beneficial outcomes were more frequently observed in the electronic alert systems.

The results of this study highlight the potential of sepsis alert systems as valuable tools for improving the outcomes of adult patients with sepsis in the ED, thus emphasizing the importance of their widespread implementation and integration into clinical practice.

Given the significant heterogeneity of the studies, careful interpretation is required, and future research with more controlled environments is needed.

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