Simplified sepsis protocols are essential to improving sepsis-related mortality rates in resource-restricted settings, but adequate training of clinicians and modified protocols are necessary for successful implementation.

Six eligible studies reported using modified-sepsis protocols to recognize early warning signs of sepsis and manage sepsis in resource-restricted settings.

Interventions comprised educational components and modified sepsis protocols (early sepsis screening tool and sepsis intervention bundle).

Studies reported increased protocol compliance with education on and standardized sepsis protocols.

While there was no significant impact on hospital lengths of stay, the sepsis-related mortality rates decreased by 22.6% even with partial implementation of the protocol.

The primary challenge in implementing sepsis protocols in resource-restricted settings is the lack of resources necessary to complete every component of the protocol successfully.

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