Serum Lactate Level and Mortality in Metformin-associated Lactic Acidosis Requiring RRT

ncbi.nlm.nih.gov January 10, 2020

This study suggests that predialysis level of serum lactate level is an important marker of mortality in MALA patients requiring renal replacement therapy (RRT) with a linear dose-response relationship.

To better evaluate the optimal prescription of RRT in MALA, it is recommended fostering an international consortium to support prospective research and large-scale standardized case collection.

A total of 253 unique cases were identified with cumulative mortality of 17.2%.

87 percent of patients had acute kidney injury (AKI).

Serum lactate level was significantly higher in non-survivors (median 22.5 mmol/L) than in survivors and so did the median blood metformin concentrations.

The survival advantage was not significantly different between the modalities of RRT.