Low hemoglobin, high serum ferritin, and high LDH in the second week are markers of disease progression and poor prognostic markers in severe adenoviral infections, emphasizing further research and targeted interventions.

The present study examined the clinical characteristics, outcomes, and biomarkers predictive of disease progression in critically ill children with adenovirus infection.

We found that infancy is vulnerable to the severe form of adenoviral disease, and several other authors have reported similar findings.

Our cohort had a 40% mortality rate for severe adenoviral infection, with Grasa et al.’s study reporting 32.7% and Rajbanshi et al.’s study reporting 27.8%.

These findings emphasize the need for proactive measures to address and mitigate the impact of adenoviral infections.

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