Intensive care unit (ICU)-acquired infections can be serious complications of medical care of critically ill patients. Despite multiple tested and implemented preventive measures for such infections, their incidence is persistently high, whereas coherence of infection prevention practices in ICUs across the globe remains low.

The heterogeneity in practice reflects the—perceived—low level of evidence of effectiveness provided by clinical research.

In this issue of Intensive Care Medicine, another piece of evidence is added to the landscape of infection prevention in ICUs.

Although this study will most likely not change current practices, its design can serve as an example for delivering convincing evidence in the future.

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