The authors concluded that high suPAR levels were associated with Acute Kidney Injury (AKI) in various clinical and experimental contexts.

This cohort study reports that suPAR was associated with subsequent AKI in several cohorts of patients exposed to intra-arterial contrast material for coronary angiography, who underwent cardiac surgery, or who were critically ill.

Furthermore, it appears that suPAR may be directly involved in the pathogenesis of AKI by sensitizing kidney proximal tubules to injury through modulation of cellular bioenergetics and increased oxidative stress.

The suPAR level was assessed in 3,827 patients who were undergoing coronary angiography, 250 who were undergoing cardiac surgery, and 692 who were critically ill.

AKI developed in 318 patients (8%) who had undergone coronary angiography.

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