Beginning in 2013, New York State implemented regulations mandating that hospitals implement evidence-based protocols for sepsis management, as well as report data on clinical outcomes to the state government.

This study examines mortality within 30 days of admission with sepsis. This large scale study, included over 1,000,000 patient episodes across 509 hospitals, with one third in New York State (NYS). The mean age was 69.5 years and 47.9% were female.

In New York State, mandated protocolized sepsis care was associated with a greater decrease in sepsis mortality compared with sepsis mortality in control states that did not implement sepsis regulations.

Because baseline mortality rates differed between New York and comparison states, it is uncertain whether these findings are generalizable to other states.

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