Platelet count drop by greater than 40% following continuous renal replacement therapy (CRRT) initiation is associated with an increased risk of secondary infection, particularly in patients with thrombocytopenia at the time of continuous renal replacement therapy initiation.

Further research is needed to evaluate the impact of both continuous renal replacement therapy and platelet loss on subsequent infection risk.

Among 797 eligible patients, 253 had thrombocytopenia at continuous renal replacement therapy initiation.

The primary predictor variable was a decrease in platelets from precontinuous renal replacement therapy levels of greater than 40% or less than or equal to 40%, although multiple cut points were analyzed.

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