The CLOVERS trials is an open label RCT that did not demonstrate any difference (beneficial or harmful) from using a restrictive fluid strategy over a liberal fluid strategy in sepsis-induced hypotension.

Do whatever you please for now, although for practical reasons I am still leaning toward earlier vasopressors in sepsis.

No infusion site extravasations were reported in this study, and the only skin complications occurred in the liberal fluid group.

In other words, as we already knew, peripheral vasopressors are safe and clearly part of the standard of care.

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