Asthma is a chronic airway inflammatory condition that affects millions of people worldwide. It presents with reversible bronchoconstriction that makes it difficult for patients to breathe. Asthma flare-ups have several triggers, but the symptoms are similar, including wheezing, coughing, shortness of breath, and chest tightness.

Severe asthma exacerbation is described as symptomatic asthma that is unresponsive to inhaled asthma medications and is only responsive to steroids in oral or intravenous forms.

Asthma-related deaths occur during episodes of asthma exacerbation.

Vitamin D is a steroid-derived vitamin produced by the body and found in some foods.

Administration of doses of vitamin D can also help maintain an adequate level of the vitamin.

Vitamin D plays a vital role in regulating the level of calcium in the body and bone remodeling processes.

It also has an immunomodulatory effect on innate and adaptive immunity within the body and that partially explains its links to inflammation-induced epithelial changes seen in asthma.

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