Vasopressin loading may be safely introduced for septic shock. Vasopressin loading may be used to predict responses to its continuous infusion and select appropriate strategies to increase blood pressure.

92 patients were registered during the study period and examined.

62 patients with a MAP change > 22 mmHg were assigned as responders and the others as non-responders.

Blood adrenocorticotropic hormone levels were significantly higher in non-responders.

Stroke volume variations were higher in responders before loading, while stroke volume and dP/dtmax were higher in responders after loading.

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