This systematic review and meta-analysis investigated the efficacy of Vitamin C as a treatment for COVID-19, focusing on key patient outcomes like mortality and critical care resource utilization.

Objective: To determine if Vitamin C supplementation significantly improves clinical outcomes in patients with COVID-19.

The analysis incorporated thirteen studies involving a large sample of 12,062 patients. The quality of the evidence ranged from very low to moderate, but most included studies had a low to indeterminate risk of bias.

The findings revealed that Vitamin C did not significantly improve the primary outcomes of 28-day mortality or in-hospital mortality when compared to standard care or placebo.

Vitamin C also showed no significant benefit across the secondary outcomes measured.

Despite the widespread clinical interest in Vitamin C for COVID-19 management, the current evidence suggests that it does not significantly improve patient outcomes. The authors conclude that further high-quality, multicenter trials are necessary to fully clarify any potential role Vitamin C might have in treating the disease.

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