TNF-α, PCT, IL-8, and HBP Prognostic Value Combined with APACHE II Score in Sepsis Patients

jidc.org April 2, 2025

Serum TNF-α, PCT, IL-8, and HBP levels influenced sepsis patient prognosis, and their combined detection with APACHE II score provided a high predictive value for patient outcomes.

Patients were divided into sepsis and septic shock groups based on sepsis-3 criteria, with non-sepsis individuals as controls.

Serum TNF-α, PCT, IL-8, and HBP levels; and APACHE II scores were recorded upon intensive care unit (ICU) admission.

The diagnostic value was evaluated using receiver operating characteristic (ROC) curves and areas under the curves (AUCs).

Correlation analysis revealed that serum TNF-α (r = 0.701), PCT (r = 0.623), IL-8 (r = 0.617), and HBP (r = 0.721) were positively correlated with the APACHE II score (p < 0.05). Serum TNF-α, PCT, IL-8, HBP levels, and APACHE II scores were significantly higher in non-survivors than survivors (p < 0.05).