Vasopressor initiation within 1 hour of fluid loading was associated with higher 28-day mortality in patients with septic shock.

The median time from the initial fluid bolus to vasopressor was shorter in the early group (0.3 vs 2.3 hr).

There was no significant difference in the fluid bolus volume within 6 hours (33.2 vs 35.9 mL/kg) between the groups.

The Sequential Organ Failure Assessment score and lactate level on day 3 in the ICU were significantly higher in the early group than that in the late group (Sequential Organ Failure Assessment, 9.2 vs 7.7; lactate level, 2.8 vs 1.7 mmol/L).

In multivariate Cox regression analyses, early vasopressor use was associated with a significant increase in the risk of 28-day mortality.

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