Mortality due to severe infections in the intensive care unit (ICU) remains high despite recent therapeutic advancements. It is believed that ICU pathogens are relatively different from those in the general wards as they commonly have reduced antibiotic susceptibility. However, despite profound physiological and pharmacokinetic differences to the non-critically ill population, critically ill patients are typically given conventional antibiotic dosing regimens, which increase the likelihood of therapeutic failures and the emergence of bacterial resistance, according to an Editorial published in Critical Care.

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