A comparison between sepsis-2 and sepsis-3 populations using a national critical care database. In an ICU database, compared with Sepsis-2, Sepsis-3 identifies a similar sepsis population with 92% overlap and much smaller septic shock population with improved predictive validity.

From among 197,724 Sepsis-2 severe sepsis and 197,142 Sepsis-3 sepsis cases, we identified 153,257 Sepsis-2 septic shock and 39,262 Sepsis-3 septic shock cases.

The extrapolated population incidence of Sepsis-3 sepsis and Sepsis-3 septic shock was 101.8 and 19.3 per 100,000 person-years, respectively, in 2015.

Sepsis-2 severe sepsis and Sepsis-3 sepsis had similar incidence, similar mortality and showed significant risk-adjusted improvements in mortality over time.

High-quality, national, ICU database of 654,918 consecutive admissions to 189 adult ICUs in England, from January 2011 to December 2015 was used for the study.

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