In critically ill children with hyperglycemia requiring inotropic support and/or mechanical ventilation, early enteral nutrition was independently associated with better clinical outcomes.

Of 608 eligible subjects, 331 (54%) received early enteral nutrition.

Both early enteral nutrition and no early enteral nutrition groups had similar daily caloric intake over the first 8 study days.

After controlling for age, body mass index z scores, primary reason for ICU admission, severity of illness, and mean Vasopressor-Inotrope Score at the time of randomization, and adjusting for site, early enteral nutrition was associated with lower 90-day hospital mortality.

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