Adult sepsis survivors experience an increased hazard of major cardiovascular events compared to survivors of a non-sepsis hospitalization.

254,241 adult sepsis survivors were matched to adult survivors of non-sepsis hospitalization episodes.

Sepsis survivors experienced an increased hazard of major cardiovascular events compared to non-sepsis survivors, which was more pronounced in younger patients.

Sepsis survivors also faced an increased hazard of venous thromboembolism and all-cause death.

Sensitivity analyses yielded consistent results.

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