In this study, serial bio-ADM samples in the ICU had limited predictive power for mortality in critically ill COVID-19 patients when looking at absolute values.

Still, relative changes over time showed a much better prediction.

Bio-ADM did not predict severe ARDS or length of stay, which may be due to the limited sample size.

There was an association between bio-ADM and AKI, and bio-ADM predicted the need for renal replacement therapy.

Further studies are warranted to investigate the pathophysiological role of bio-ADM in COVID-19 and develop prediction models or aid the development of future treatments.

Read More