Association of Vancomycin Plus Piperacillin-tazobactam with Early Changes in Creatinine vs. Cystatin C

Association of Vancomycin Plus Piperacillin-tazobactam with Early Changes in Creatinine vs. Cystatin C

Although dozens of studies have associated vancomycin + piperacillin–tazobactam with increased acute kidney injury (AKI) risk, it is unclear whether the association represents true injury or a pseudotoxicity characterized... read more

Bedside Procedures for the Intensivist

Bedside Procedures for the Intensivist

Bedside Procedures for the Intensivist delivers practical tips and clear, step-by-step instruction on the most common procedures in the ICU. The convenient and portable handbook focuses on ultrasound-guided techniques, including... read more

A Cold Case of Superior Vena Cava Syndrome

A Cold Case of Superior Vena Cava Syndrome

A 61-year-old woman with hypertension, diabetes mellitus, hyperlipidemia, coronary artery disease, congestive heart failure (s/p PPM/ICD), pulmonary embolism (on warfarin), end-stage renal disease (on HD via right internal... read more

Principles of Intensive Care, CCU, ICU and Dialysis (Book 1): Vascular Access, ICU and Drug Treatment, Hemodynamic Monitoring

Principles of Intensive Care, CCU, ICU and Dialysis (Book 1): Vascular Access, ICU and Drug Treatment, Hemodynamic Monitoring

Anesthesia and intensive care are one of the most important disciplines in medical, paramedical and nursing sciences and requires spending attention, time, gaining enough information and experience to be able to evaluate... read more

Remdesivir Treatment for Hospitalized COVID-19 Patients in Canada

Remdesivir Treatment for Hospitalized COVID-19 Patients in Canada

Remdesivir, when compared with standard of care, has a modest but significant effect on outcomes important to patients and health systems, such as the need for mechanical ventilation. Across 52 Canadian hospitals, we randomized... read more

Critical Care Pediatric Nephrology and Dialysis

Critical Care Pediatric Nephrology and Dialysis

This book covers all key aspects of critical care in pediatric nephrology, including acute dialysis in sick children. It also provides detailed protocols for managing fluid and electrolyte balance and dialysis in children... read more

No Such Thing As a Simple Sedation Case

No Such Thing As a Simple Sedation Case

In my CA-2 year I encountered an elderly gentleman who needed an angiogram of his dialysis fistula. After starting the propofol infusion I placed an oral airway because his tongue obstructed his breathing by flipping back... read more

Management of late onset urea cycle disorders-a remaining challenge for the intensivist?

Management of late onset urea cycle disorders-a remaining challenge for the intensivist?

Awareness of urea cycle disorders in adults intensive care units can optimize early management and accordingly dramatically improve prognosis. By preventing hyperammonemia to induce brain edema and herniation leading to death. Hyperammonemia... read more

Association of Initiation of Dialysis with Hospital Length of Stay and Intensity of Care in Older Adults With Kidney Failure

Association of Initiation of Dialysis with Hospital Length of Stay and Intensity of Care in Older Adults With Kidney Failure

In this cohort study, compared with non-dialysis care, patients who received maintenance dialysis spent more time in the hospital and were more likely to be admitted to intensive care units. This finding suggests trade-offs... read more

Distance Between the Tips of Central Venous Catheters Does Not Depend on Same or Opposite Site Access

Distance Between the Tips of Central Venous Catheters Does Not Depend on Same or Opposite Site Access

Central venous catheters (CVCs) are routinely required in the intensive care unit (ICU) for infusion of drugs, often concurrently with central venous dialysis catheters (CVDCs) for renal replacement therapy (RRT). Increased... read more

Ultrasound-based Clinical Profiles for Predicting the Risk of Intradialytic Hypotension in Critically Ill Patients on Intermittent Dialysis

Ultrasound-based Clinical Profiles for Predicting the Risk of Intradialytic Hypotension in Critically Ill Patients on Intermittent Dialysis

In critically ill patients on intermittent hemodialysis, the absence of hypervolemia as assessed by lung and vena cava ultrasound predisposes to intradialytic hypotension and suggests alternative techniques of hemodialysis... read more

Association Between Intravenous Contrast Media Exposure and Non-recovery From Dialysis-requiring Septic AKI

Association Between Intravenous Contrast Media Exposure and Non-recovery From Dialysis-requiring Septic AKI

This large observational study did not support an association between intravenous contrast media and adverse in-hospital outcomes in patients with septic dialysis-requiring acute kidney injury (AKI-D). Further studies are... read more

Estimated Effects of Early Diuretic Use in Critical Illness

Estimated Effects of Early Diuretic Use in Critical Illness

The main objectives of this study was to estimate the effects of diuretic use during the first 24 hours of an ICU stay on in-hospital mortality and other clinical outcomes including acute kidney injury (AKI) and duration... read more

Tigecycline in Critically Ill Patients on Continuous RRT

Tigecycline in Critically Ill Patients on Continuous RRT

Despite high dialysability, dialysis clearance displayed only a minor contribution to tigecycline elimination, being in the range of renal elimination in patients without AKI. No dose adjustment of tigecycline seems necessary... read more