Sepsis subphenotypes identified using the universally available measurement of body temperature had distinct immune profiles. Hypothermic patients, who had the highest mortality rate, also had the lowest levels of most pro- and anti-inflammatory cytokines.

Hospitalized patients from four hospitals between 2018 and 2022 with suspicion of infection were included.

A previously validated temperature trajectory algorithm was used to classify study patients into temperature trajectory subphenotypes.

Microbiological profiles, clinical outcomes, and levels of 31 biomarkers were compared between these subphenotypes.

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