Norepinephrine Usage Tips in Perioperative Medicine

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Tip 1. Looking beyond vasodilatation: use norepinephrine as first-line vasopressor but reassess the cause of hypotension before escalation.

Tip 2. Set a goal of mean arterial blood pressure above 60 mmHg, and individualize if feasible.

Tip 3. Highly diluted norepinephrine is safe to use through a dedicated peripheral catheter.

Tip 4. Consider the use of pre-diluted solutions for norepinephrine preparation.

Tip 5. Prefer continuous norepinephrine infusion instead of repeated bolus.

Tip 6. Not too much norepinephrine: set a maximal dosage and an adapted monitoring strategy.

Tip 7. Implement an institutional protocol.

Tip 8. Future directions.

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