Among hospitalised COVID-19 patients needing oxygen therapy, high dose of dexamethasone reduced clinical worsening within 11 days after randomisation as compared with low dose of dexamethasone. Further studies are necessary... read more

This book is a practical manual for anti-COVID-19. It is not only with the reference to the result of modern medical science, patients’ situation, but also take the deployment of medical resources into consideration.... read more

Multiple biomarkers prognostic for clinical outcomes were confirmed in COVACTA. Ferritin was identified as a predictive biomarker for the effects of tocilizumab in the COVACTA patient population; high ferritin levels were... read more

Critically ill COVID-19 patients frequently reactivate HSV-1 but not HSV-2. HSV-1 reactivation in critically ill COVID-19 patients was associated with an increased risk of day-60 mortality and hospital-acquired pneumonia... read more

The second edition of this highly successful book includes up-to-date notes on the step-wise management of clinical emergencies encountered in everyday intensive care units (ICU). Each thoroughly revised chapter provides... read more

The incidence of intra-abdominal hypertension (IAH) is high and still underappreciated by critical care physicians throughout the world. One in four to one in three patients will have IAH on admission, while one out of two... read more

The treatment of COVID-19 patients with Seraph®100 is well tolerated and the circuit failure rate was lower than previously reported for KRT in COVID-19 patients. Mortality corelated with late initiation of Seraph treatment... read more

There was a marked deterioration in outcomes for patients admitted to critical care at the peak of the second wave of coronavirus disease 2019 in United Kingdom (December 2020–January 2021), compared with the post-first-wave... read more

This book presents a concise, evidence-based review of extracorporeal life support (ECLS) for adult diseases. It describes the use of ECLS with patients who are experiencing severe hypoxemic respiratory failure (ARDS and... read more

Mechanical stretch of cancer cells can alter their invasiveness. During mechanical ventilation, lungs may be exposed to an increased amount of stretch, but the consequences on lung tumors have not been explored. To characterize... read more

The survival rate of patients received continuous renal-replacement therapy (RRT) treatment in our center has improved over past 10 years, and some changes have taken place during these periods. Among them, early initiation... read more

In some patients, respiratory symptoms and imaging abnormalities persist after acute coronavirus disease 2019 (COVID-19) pneumonia. The chest computed tomography (CT) generally shows diffuse parenchymal lung abnormalities... read more

Tracheal extubation generates less interest than tracheal intubation. Research, guidelines and clinical anecdotes tend to focus on airway management at the beginning of anesthesia, and it is rare for the challenges of extubation... read more

Restricting severely ill patients access to new broad-spectrum empirical drugs is not the answer. Rather there should be a focus on identifying host response to infection to differentiate between colonization or contamination... read more

The idea of using beta-blockers as a treatment for ventricular fibrillation occurred to James Black over 60 years ago. He developed propranolol and cimetidine, among other pharmacologic agents, work for which he won the Nobel... read more

While tracheal intubation (TI) characteristics vary between pediatric Emergency Departments and ICUs, outcomes are similar. Shock and limited mouth opening were independently associated with adverse TI events in the Emergency... read more

Hypovitaminosis C and vitamin C deficiency are common in critically ill patients and associated with organ dysfunction. Low vitamin C status often goes unnoticed because determination is challenging. The static oxidation... read more

Life-sustaining treatment limitation decisions were made for 18% of a COVID-19 patient cohort. Hereof, more than a third of the decisions had been made before hospital admission. Many records lacked information on patient... read more